Dove e quando
2022-06-01 | Villa Cambiaso - Salone Nobile - Via Montallegro, 1
Per il ciclo "Seminari nell'ambito dell'attività di dottorato", mercoledì 1 giugno 2022 alle ore 14:00 presso il Salone Nobile di Villa Cambiaso, Via Montallegro 1, il prof. Ross Ethier, Georgia Research Alliance Lawrence L. Gellerstedt, Jr. Eminent Scholar in Bioengineering terrà un seminario dal titolo:
“TISSUE BIOMECHANICS IN MYOPIA QUANTIFIED BY UNCONFINED COMPRESSION TESTING”
prof. Ross Ethier
Georgia Research Alliance Lawrence L. Gellerstedt, Jr. Eminent Scholar in Bioengineering
Abstract:
Myopia (near-sightedness) is a common ocular condition, with over 90% of young adults suffering from this condition in some countries. Myopia is a risk factor for blinding conditions, including retinal tears/detachment, glaucoma and myopic macular degeneration. During the development of myopia, the sclera (the white part of the eye) remodels so that the eye is “too long” and images are not sharp on the retina. Here we describe a mouse model of myopia, with emphasis on measurements of scleral biomechanics using unconfined compression testing in which the sclera is treated as a bimodular biphasic material. We can reliably induce myopia in mice by using defocusing lenses, and this induction is associated with changes in scleral tensile stiffness and permeability. We also describe a novel model for induction of myopia in the mouse based on exogenous delivery of all-trans retinoic acid (atRA) and outline major challenges in mass transfer modeling of atRA within the eye.